Table 4.: Selected studies of impaired glucose tolerance [IGT], including diabetes mellitus, in patients with DISH.

Author No. of Patients Dish Criteria Diabetic or IGT Diabetic IGT Comment
Boulet et al. [1954] [29] 8 M, 4 F “Forestier” 100% 100% NS No controls, small sample
Recordier et al. [1959] [41] 16 persons “Forestier” 56% NS NS No controls, small sample
Einaudi et al. [1960] [42] 15 M, 4 F NS 60% + 60% “many” No controls, small sample
Cassan [1963] [43] 43 persons NS 23% NS NS 6.5% controls
Ott et al. [1963] [44] 100 persons NS 50% 25% 25% Suggests association of DISH with abnormal GT
Dahmen [1967] [45] 120 persons “Forestier” 30% 20% 10% 7.3% controls, suggests association with abnormal GT
Ott et al. [1967] [46] 160 persons NS 55% 22% 33% No controls but high prevalence abnormal GT
Perrotin [1968] [47] 59 persons NS 61% + 61% NS No controls but high prevalence abnormal GT
Lequesne et al. [1970] [48] 43 persons with DISH, 46 without DISH “Forestier” DISH = 23%
Control =6.5%
[p<0.05]
DISH = 23%
Control =6.5%
[p<0.05]
NS Significant association between DISH and diabetes
Julkunen et al. [1971] [3] 94 M, 70 F with DISH / same number without DISH Julkunen DISH M 19.1%
DISH F 28.6%
Control M 7.4%
Control F 12.8%
[p < 0.05]
NS NS Significant association between DISH and hyperglycaemia
Bregeon et al. [1973] [49] 21 persons “Forestier” 43% 30% 13% No controls
Henrard and Bennett [1973] [50] 48 DISH
35 non-DISH
Pima Indians
“Forestier” 50% DISH
28% non-DISH
[p<0.05]
NS 50% had OGTT, 2hr glucose> 160mg% Significant association between DISH and hyperglycaemia
Harris et al. [1974] [4] 17 M, 17 F Harris 8.5% + 8.5% + Only 6 tested- all “normal” No controls
Utsinger et al. [1976] [32] 25 M, 5 F Resnick 17% NS Fasting hyperglycaemia No controls
Rosenthal et al. [1977] [51] 50 persons Resnick 32% NS NS No controls
Tsukamoto et al. [1977] 157 M, 18 F Resnick “no correlation between DISH and diabetes” in males NS NS Hiroshima survivors
Resnick et al. [1978] [33] 21 M Resnick 29% NS NS No controls
Arlet et al. [1978] [52] 100 M “Forestier” 14% 9% 5% No controls
El Garf and Khater [1984] [53] 38 persons Resnick 37% NS NS No controls
Cassim et al. [1990] [54] 21 persons DISH
479 no DISH
Resnick 52.4% 33.3% history DM in DISH, 7.7% in controls
[p<0.0001]
19.1% IGT to glucose load High diabetes in DISH group, but small number of patients
Troillet and Gerster [1993] [35] 17 M, 8 F DISH
17 M, 8 F no DISH, matched for age, BMI.
Resnick No difference No difference Fasting hyperglycaemia IGT not different, but small numbers
Daragon et al. [1995] [36] 50 persons -DISH >60yrs
50 controls - matched sex, age, weight, height
Resnick No difference No difference No difference in glucose tolerance No association DISH and Dbs / hyperglycaemia.
Vezyroglou et al. [1996] [55] 100 DISH
100 controls, matched age, sex, BMI, excess body weight
Resnick No difference 22% in DISH, 3% in Controls
[p<0.0001]
  Increased dyslipidemia /hyperuricemia
and DM in DISH [p<0.0001]
Kiss et al. [2002] [25] 69 M / 62 F -DISH; 69 M/62 F men /women - spondylosis Resnick DISH =19.8%
Control = 9.1%
[p<0.05]
DISH =19.8%
Control = 9.1%
[p<0.05]
NS Significant association between DISH and diabetes
Mader et al. [2009] [27] 13 M / 34 F DISH; 48 age-sex matched controls Resnick NS DISH =49%
Control = 33%
NS
DISH =40%
Control = 10%
Fasting glucose >110 mg/dL
[p<0.05]
Significant association between DISH and hyperglycaemia
Eckertova et al. [2009] [56] 20 M, 9 F-DISH, 8 M, 9 F- non-DISH, matched for age, BMI. Resnick DISH = 41.4%
Control =7.8%
[p<0.05]
NS DISH = 41.4%
Control =7.8%
[p<0.05]
Significant association between DISH and hyperglycaemia
Zincarelli et al. [2012] [40] DISH 105 M / 27 F
Non-DISH 231 M /73 F
Resnick No difference in rates of T2DM or fasting blood glucose >100mg/dl     All patients had severe cardiac disease –no healthy controls

M = males, F = females, GT =glucose tolerance, IGT = Impaired glucose tolerance, T1DM = Type 1 diabetes mellitus, T2DM = Type 2 diabetes mellitus, NS = not stated, Dbs =diabetes, “Forestier” indicates that diagnosis based on typical features of Forestier et al. description [11].