Author | Patients | Dish Criteria | Methods | Result | Comment |
---|---|---|---|---|---|
Bregeon et al. [1973] [49] | 10 M | “Forestier” | Basal and post-glucose GH | GH-Normal levels | Small sample |
Harris et al. [1974] [4] | 5 younger persons | Harris | NS | GH-Normal levels | Small sample |
Resnick et al. [1978] [33] | 6 persons | Resnick | NS | GH -normal levels | Small sample. |
Littlejohn and Smythe [1981] [61, 63] | 11 M DISH 8 M, age/ weight -matched no DISH |
Resnick | Fasting basal and post-glucose GH, IGF-1 | GH- no difference IGF-1 –no difference |
Small sample, controlled for BMI. |
Altomonte et al. [1992] [64] | 6 M, non-obese DISH, 10 M, weight-matched no DISH |
Resnick | Fasting basal and post insulin tolerance test [ITT] GH | Basal GH not elevated, significant GH elevation post-ITT compared to control [p<0.05] | Only study to show post stimulation elevation of GH |
Denko et al. [1994] [62] | 14 white M DISH, 22 M no DISH 8 white F / 8 black F DISH, 22 white F/ 10 black F no DISH |
Resnick | Fasting morning GH, IGF-1 | GH- elevated IGF-1-no difference in males/ black females, elevated in white females |
Study confounded by significant differences in weight, with DISH groups being heavier. |
Denko et al. [1996] [65] | 8 M DISH 12 M OA 22 M no DISH |
Resnick | Fasting morning GH, IGF-1 | Serum IGF-1 - same as controls, synovial IGF-1 same as OA. Serum GH- higher [and same] in DISH and OA than controls, synovial GH same as OA group. |
All DISH patients had knee effusions, no matching for weight |
Denko et al. [2002] [66] | 15 M DISH 15 M controls |
NS | Fasting morning GH, IGF-1 | GH but not IGF-1 lower in asymptomatic DISH patients, but NS | Poorly controlled study |
Denko et al. [2003] [67] | 19 M DISH 34 M no DISH, not controlled for weight |
Resnick | Fasting morning intra-erythrocyte GH | Intra-erythrocyte GH same in DISH and controls | |
Sencan et al. [2005] [60] | 133 T2 DM outpatients 133 age, sex, weight –matched, outpatient controls |
Resnick | Fasting IGF-1 | No difference | |
Denko and Malemud [2006] [68] | 11 DISH with BMI 23-28 10 DISH with BMI >28 |
Resnick | Fasting morning serum GH, IGF-1 | GH and IGF-1 no different between BMI groups | “Additional” data from 25 DISH patients showed no correlation between BMI and GH or IGF-1. |
Eckertova et al. [2009] [56] | 20M, 9F -DISH 8M, 5F- no DISH, matched for age, |
Resnick | Fasting and post-OGTT serum GH, IGF-1, IGF-BP3 | No difference between groups |