Established RA TNFi Treatment |
Rheumatoid Factor Positive (RF+) |
Rheumatoid Factor Negative (RF-) |
P Value |
Total N with RF results available (238)(% of included patients)
|
178 (75%) |
60 (25%) |
|
% Female |
82% |
72% |
0.7 |
Age (SD) |
57 (14) |
56 (12) |
0.6 |
Disease duration {years} (SD) |
12 (8) |
9 (8) |
0.017 |
N with available paired HAQ-DI results at 1 year# (% of included patients) N included 128 |
90 (70%) |
38 (30%) |
|
Baseline HAQ-DI (SD)(0=3) prior to TNFi |
1.44 (0.63) |
1.41 (0.63) |
0.8 |
HAQ-DI change Baseline to Year 1 |
-0.356 (0.60) |
-0.126 (0.54) |
0.04 |
N with available paired Pain results at 1 year# (% of included
patients) N included 109 |
77 (71%) |
32 (29%) |
|
Baseline PAIN (SD)(0-3) |
1.92 (0.67) |
1.93 (0.67) |
0.9 |
PAIN change Baseline to Year 1 |
-0.725 (0.86) |
-0.332 (0.82) |
0.03 |
Mean treatment duration for first TNFi {Years} (SD)N=238 |
2.8 (2.0) |
2.3 (1.6) |
0.1 |
Proportion of patients still on same TNFi after at last follow up from the
included 238 patients |
68% |
62% |
0.5 |
Note of 340 identified patients, only 238 had some data available for analysis. SD = Standard Deviation; Age and Disease Duration is shown in Years; p-Value with significance at
<0.05, #Only the patients with available data compose the N for each result. The demographics (age, sex, disease duration, baseline HAQ-DI, baseline pain) of the patients with
available data was not significantly different from those with incomplete data.