Fig. (1) Disease activity and inflammatory measures during the first 5 years of follow-up. Group 1 is patients included between 1992 and 1999, group 2 included between 2000 and 2006. Data are reported separately for men and women. A presents the mean DAS28 in the separate groups over time, B presents the mean ESR in the separate groups over time. C and D presents mean SJC28 and mean TJC28 in the separate groups over time. DAS28; 28 joints-Disease Activity Score, ESR; Erythrocyte sedimentation rate, SJC28; Swollen Joint Count 28, TJC28; Tender Joint Count 28.