| n or median [25th – 75th percentile] | |
|---|---|
| N patients | 50 |
| Sex ratio, F/M | 27/23 |
| Age, years | 67 [50; 72] |
| BMI | 26.9 [23.9; 32.4] |
| Underlying disease | – |
| asthma | 15 |
| COPD | 26 |
| bronchiectasis | 6 |
| sarcoidosis | 2 |
| interstitial disease | 1 |
| Tobacco history | – |
| current-smoker, n | 9 |
| ex-smoker, n | 20 |
| never-smoker, n | 21 |
| pack-years | 33 [19; 50] |
| MRC score | 2.0 [1.0; 3.0] |
| Lung function | – |
| FEV1, L | 1.72 [1.27; 2.12] |
| FEV1, % predicted | 59 [53; 65] |
| FEV1, Z-score | -2.53 [-2.96; -2.12] |
| FVC, L | 2.22 [1.64; 2.79] |
| FVC, % predicted | 63 [54; 67] |
| FVC, Z-score | -2.55 [-2.88; -2.20] |
| Slow inspiratory VC, L | 2.22 [1.61; 2.80] |
| FEV1/FVC | 0.74 [0.70; 0.78] |
| FEV1/FVC, % predicted | 94 [90; 98] |
| FEV1/FVC, Z-score | -0.68 [-0.98; -0.18] |
| IC, L | 1.62 [1.20; 2.20] |
| TLC, L | 4.93 [4.16; 6.37] |
| TLC, % predicted | 90 [85; 95] |
| FRC, L | 3.31 [2.89; 4.28] |
| FRC, % predicted | 110 [99; 131] |
| RV, L | 2.80 [2.13; 3.40] |
| RV, % predicted | 132 [117; 154] |
| RV/TLC | 0.55 [0.49; 0.64] |
| RV/TLC, % predicted | 142 [132; 152] |
| sRaw, kPa.s | 1.63 [1.15; 2.26] |
| Raw, kPa.s/L | 0.41 [0.30; 0.52] |
| Impulse Oscillometry | – |
| Zrs5Hz, kPa.s/L | 0.48 [0.40; 0.63] |
| Zrs5Hz, % predicted | 147 [128; 175] |
| Rrs5Hz, kPa.s/L | 0.42 [0.34; 0.51] |
| Rrs5Hz, % predicted | 134 [121; 167] |
| Xrs5Hz, kPa.s/L | -0.16 [-0.23; -0.11] |
| Xrs5Hz, % predicted | 166 [106; 190] |
| ∆Rrs5Hz-20Hz, kPa.s/L | 0.15 [0.10; 0.21] |
| ∆Rrs5Hz-20Hz, % predicted | 213 [165; 296] |
| AX, Hz.kPa.s/L | 1.41 [0.91; 1.97] |
| AX, % predicted | 363 [268; 514] |
| Bronchodilator response | – |
| FEV1, % increase | +8 [+1; +12] |
| FVC, % increase | +6 [+1; +12] |
| IC, % increase | +12 [+3; +22] |
| Zrs5Hz, % decrease | 0 [-9; +12] |
| Rrs5Hz, % decrease | +12 [-3; +21] |
| Xrs5Hz, (post-pre) | 0.03 [0.01; 0.07] |
| ∆Rrs5Hz-20Hz, % decrease | +25 [+10; +33] |
| AX, % decrease | +32 [+17; +47] |