| Medications that Alter the Plasma Glucocorticoid Levels |
| Inducers of Cytochrome P450: Decreases GC Level |
- Antiepileptics : Barbiturate, Carbamazepine, Phenytoin
- Bile acid sequestrants
- Antibiotics : Rifampicin
|
| Inhibitors of Cytochrome P450: Increases GC Level |
| 1. Inhibitors of cytochrome P450 dependent CYP 3A4 inhibitors |
- Antibiotics : Macrolide, Clarithromycin
- Anti fungal : Fluconazole, Itraconazole, Ketoconazole, Voriconazole
- Anti arrhythmic : Amiodarone, Lidocaine
- Calcium channel blockers: Diltiazem, Verapamil
- HIV drugs : Ritonavir, Indinavir
- HMG CoA reductase inhibitors: Atorvastatin
|
| 2. Inhibitors of cytochrome P450 dependent CYP 2D6 |
- Antipsychotics/Antidepressents:Amitryptiline, Haloperidol, Resperidone, Clozapine, Fluoxetine.
- Cardiac drugs: Flecainide, Propafenone, Carvedilol, Metoprolol
|