Medications that Alter the Plasma Glucocorticoid Levels |
Inducers of Cytochrome P450: Decreases GC Level |
- Antiepileptics : Barbiturate, Carbamazepine, Phenytoin
- Bile acid sequestrants
- Antibiotics : Rifampicin
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Inhibitors of Cytochrome P450: Increases GC Level |
1. Inhibitors of cytochrome P450 dependent CYP 3A4 inhibitors |
- Antibiotics : Macrolide, Clarithromycin
- Anti fungal : Fluconazole, Itraconazole, Ketoconazole, Voriconazole
- Anti arrhythmic : Amiodarone, Lidocaine
- Calcium channel blockers: Diltiazem, Verapamil
- HIV drugs : Ritonavir, Indinavir
- HMG CoA reductase inhibitors: Atorvastatin
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2. Inhibitors of cytochrome P450 dependent CYP 2D6 |
- Antipsychotics/Antidepressents:Amitryptiline, Haloperidol, Resperidone, Clozapine, Fluoxetine.
- Cardiac drugs: Flecainide, Propafenone, Carvedilol, Metoprolol
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