| Clinical Features | Spontaneous Cushing’s Syndrome | Iatrogenic Cushing’s Syndrome |
|---|---|---|
| H/o exogenous steroid intake | Absent | Present |
| Onset and progression | Develop gradually | More abrupt with striking features |
| Psychological features | Less severe | More severe |
| Hypertension | More common | Less common |
| Hirsutism, virilising feature | More common | Less common |
| Menstrural irregularities | More common | Less common |
| Glucoma, ocular features | Less common | More common |
| Avascular necrosis | Less common | More common |
| Benign intracranial hypertension | Less common | More common |
| Pancreatitis | Less common | More common |
| Osteoporosis | Less common | More common |
| Spinal epidural lipomatosis | Uncommon | Rarely reported |
| Serum cortisol | Increased | Suppressed |
| ACTH | Increased / decreased | Suppressed |
| Adrenal suppression | Absent | Present |