Clinical Features |
Spontaneous Cushing’s Syndrome |
Iatrogenic Cushing’s Syndrome |
H/o exogenous steroid intake |
Absent |
Present |
Onset and progression |
Develop gradually |
More abrupt with striking features |
Psychological features |
Less severe |
More severe |
Hypertension |
More common |
Less common |
Hirsutism, virilising feature |
More common |
Less common |
Menstrural irregularities |
More common |
Less common |
Glucoma, ocular features |
Less common |
More common |
Avascular necrosis |
Less common |
More common |
Benign intracranial hypertension |
Less common |
More common |
Pancreatitis |
Less common |
More common |
Osteoporosis |
Less common |
More common |
Spinal epidural lipomatosis |
Uncommon |
Rarely reported |
Serum cortisol |
Increased |
Suppressed |
ACTH |
Increased / decreased |
Suppressed |
Adrenal suppression |
Absent |
Present |