Table 5: Summary of patents filed for hematopoietic stem cells used for treating ocular disorders.

No.	Cell Type	Patent No.	Disease	Summary	Trial Status	Route of Administration	Refs.
1	Hematopoietic stem cells	WO2004/01059A2	Ocular vascular disease e.g. AMD, diabetic retinopathy	Isolated bone-marrow derived Lin- hematopoietic stem cells comprising endothelial progenitor cells with markers CD31 and c-kit that can be used for development of retinal vessels as well as prevent degeneration of these vessels. The cells are transfected with a therapeutically beneficial gene which specifically targets neovasculature and inhibits new retinal vessel formation acting as a vasculotrophic and neurotrophic agent.	Pre-clinical	Intravitreal injection	[48]
2	Hematopoietic stem cells	US2010/0068141A1	Pre-proliferative retinopathy, diabetic retinopathy, choroidal neovascularization, glaucoma, AMD, RP, Stargardt’s disease, Best’s macular dystrophy etc.	The patent claims a method for treating ocular diseases recruiting stem cells which are induced by heat shock, within which the heat shock is induced by a small compound or an expression vector. Further the invention portrays modes of administration and pharmaceutical compositions for ameliorating ocular diseases.	Pre-clinical	Oral, rectal, topical, intraocular, buccal, intravaginal, intracisternal, intracerebroventricular, intratracheal, nasal, transdermal, device/implants, or parenteral routes	[49]