Efficacy and Safety of Phyllanthus Amarus Cream Treatment in Knee Osteoarthritis

Table 4: VAS and WOMAC scores in pre- to post-treatment in period 2 and 4 weeks all groups.

Weeks Parameters	placebo cream (N=20) Mean ± SD			Phyllanthus Amarus cream (n=20) Mean ± SD			NSAIDs cream (n=20) Mean ± SD
Weeks Parameters	0	2	4	0	2	4	0	2	4
VAS	66.10± 9.71	64.05± 8.73	63.05± 8.69	65.30 ± 10.67	46.20± 9.06*	25.75± 10.04*	67.5± 9.81	50± 6.88*^,#	29.95± 7.69*^,#
WOMAC	94.55 ± 20.43	90.60± 18.87	88.2± 21.59	100± 18.73	64.45± 9.44*	35.40± 15.09*	89.75± 23.83	69.60± 15.74*^,#	36.7± 11.40*^,#

VAS, visual analog scale: WOMAC, Western Ontario and McMaster Universities O-osteoarthritis Index questionnaire.
* showed significant pretreatment in each group, # showed significant post-treatment wered to a period of 2 weeks in each group, p < 0.001. Data are expressed as mean ± standard deviation.