Fig. (2) Interaction between free and bound fractions of testosterone and cortisol (based on Molina [38], 2010 and Cumming [34], 1986). S: cortisol production rate. Clivre: free cortisol (biologically active). CCBG: cortisol + cortisol binding globulin. Calbu: cortisol + albumin. ss: output of free cortisol to cells + metabolization. A: testosterone production rate. Tlivre: free testosterone (biologically active). TSHBG: testosterone + sex hormone-binding globulin. Talbu: testosterone + albumin. aa: output of free testosterone to cells + metabolization. Fc: cortisol's inhibitory effect.