Fig. (3) The new TNFα-NFκB pathway model (Model B) includes three new proteins MEKK3 (m32), FLIP (m33) and TRAF1 (m35). Circles (with m and a number) represent various states for protein concentration (i.e. kinetic constants), and directed arrows represent dynamic relations (i.e. kinetic equations). The protein complex TNF/TNFR1/TRADD/RIP1/TRAF2/MEKK3/IKK connects to NFκB is colored red. The new protein complexes are colored magenta, e.g. Caspase8/FLIP (m34), RAF1/Caspase8* (m36) and TRAF2/TRAF1c(m38).