Table 1: Definitions of Single Organ Failure

Organ Definition
Liver Failure SOFA ≥3 (serum bilirubin ≥ 6 mg/dL) or Maddrey’s DF >32
Renal Failure Defined as AKI, according to the Acute Kidney Injury Network criteria
Nervous system failure SOFA ≥3 (Glasgow Coma Scale ≤9)
Respiratory failure SOFA ≥3 (PaO2/FiO2 <200 and mechanically ventilated)
Circulatory failure SOFA ≥3 (use of norepinephrine, epinephrine, or dopamine [dopamine >5 μg/kg/min])
Coagulation failure SOFA ≥3 (platelet count <50,000/μL)

SOFA: Sequential Organ Failure Assessment.