Fig. (4) Proposed scheme summarizing the interplay of the studied molecules implicated in IH pathogenesis. The ACE II decrease results in less Ang (1-7) production and NOS activation. In parallel, the increase of ADMA leads to NOS blocking and thereby NO synthesis inhibition, despite the high plasma collectrin and VEGF-C/TonEBP expression. Moreover, ET-1 is increased. All in all, the vasomotor balance is shifted from vasodilation to a vasoconstriction status.