The Open Urology & Nephrology Journal




ISSN: 1874-303X ― Volume 12, 2019

Vascular Access Calcification and Arteriovenous Fistula Maturation



Timmy Lee*
Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, 1720 2nd Ave. South, Zeigler Research Building 524, Birmingham, AL 35294-0007, USA

Abstract

The vascular access serves as the “lifeline” for the hemodialysis patient, but in recent years has become the “Achilles Heel” of the hemodialysis procedure. The vascular health of the vessels used to create arteriovenous accesses is paramount to vascular access maturation and successful outcomes. Vascular calcification is widely present in the vessels of chronic kidney disease (CKD) and end stage renal disease (ESRD) patients, and may also potentially impact the vascular access remodeling process. Few studies have been published to date evaluating vascular calcification as it relates to vascular access outcomes. However, an improved understanding of how vascular calcification plays a pathophysiological role in hemodialysis vascular access dysfunction may improve therapies to treat arteriovenous fistula (AVF) non-maturation and the health of the vessels prior to vascular access creation.

Keywords: Arteriovenous fistula, chronic kidney disease, hemodialysis vascular access dysfunction, vascular calcification..


Article Information


Identifiers and Pagination:

Year: 2014
Volume: 7
Issue: Suppl 1: M3
First Page: 22
Last Page: 25
Publisher Id: TOUNJ-7-22
DOI: 10.2174/1874303X01407010022

Article History:

Received Date: 3/9/2013
Revision Received Date: 1/4/2014
Acceptance Date: 4/4/2014
Electronic publication date: 30 /5/2014
Collection year: 2014

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© Timmy Lee; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, 1720 2nd Ave. South, Zeigler Research Building 524, Birmingham, AL 35294-0007, USA; Tel: 205-975-9322; Fax: 205-996-6465; E-mail: txlee@uab.edu




INTRODUCTION

Vascular access dysfunction remains a major cause of morbidity and mortality in hemodialysis patients [1Lee T. Novel paradigms for dialysis vascular access: downstream vascular biology - is there a final common pathwayκ. Clin J Am Soc Nephrol 2013; 8(12): 2194-01.-4Dhingra RK, Young EW, Hulbert-Shearon TE, Leavey SF, Port FK. Type of vascular access and mortality in U.. hemodialysis patients. Kidney Int 2001; 60: 1443-51.]. Arteriovenous fistulas (AVF) remain the preferred form of vascular access due to the lower rates of infection and maintenance procedures to treat stenosis compared to arteriovenous grafts (AVG), if the AVF successfully matures for hemodialysis. However, recent publications have reported a high proportion of non-maturing AVFs among our hemodialysis patients [5Dember LM, Beck GJ, Allon M , et al. Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA 2008; 299: 2164-71.-7Allon M. Current management of vascular access. Clin J Am Soc Nephrol 2007; 2: 786-800.]. Furthermore, several recent publications have also demonstrated the presence of neointimal hyperplasia from patient veins and arteries collected at the time of new surgical access creation [8Allon M, Litovsky S, Young CJ , et al. Medial fibrosis. vascular calcificaion.intimal hyperplasia., and arteriovenous fistula maturation. Am J Kidney Dis 2011; 58: 437-.-13Alpers CE. Prominent neointimal hyperplasia is common in veins utilized for AV fistula creation The Hemodialysis Fistula Maturation (HFM) study [Abstract]. J Am Soc Nephrol 2012; 23: 14A.]. This suggests that the baseline vascular health of both the arteries and veins used to create new vascular accesses may play an important role in AVF maturation [1Lee T. Novel paradigms for dialysis vascular access: downstream vascular biology - is there a final common pathwayκ. Clin J Am Soc Nephrol 2013; 8(12): 2194-01.]. Vascular calcification has been demonstrated to play an important role in the cardiovascular mortality in CKD and ESRD patients [14London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end stage renal disease impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003; 18: 1731-40.], but with fewer published studies looking at its role in hemodialysis vascular access. In the context of AVF maturation, this review will; (1) discuss the pathophysiology of vascular calcification in CKD and ESRD, (2) highlight the major research studies evaluating vascular calcification in hemodialysis vascular access, and (3) identify future areas of research to better elucidate the role of vascular access calcification in hemodialysis vascular access dysfunction.

PATHOPHYSIOLOGY OF VASCULAR CALCIFICATION IN CKD

Cardiovascular events are the major etiology of mortality in ESRD patients [15U S Renal Data System (USRDS) 2009 Annual Data Report.Atlas of CKD and ESRD in the United Sttes.National Institutes of Health., National Institute of Diabetes and Digestive and Kidney Diseases. Bethesda 2009.]. Arterial vascular histologic changes and remodeling occur in response to increasing hemodynamic alterations and increasing uremia from progressive CKD. The arterial vascular pathology associated with CKD and ESRD is commonly characterized by the presence of significant intimal and medial calcification [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.]. In addition to CKD and ESRD, calcification has also been associated with increasing age, hypertension, diabetes, dyslipidemia, and smoking [17Guerin AP, London GM, Marchais SJ, Metivier F. Arterial stiffening and vascular calcification in end stage renal disease. Nephrol Dial Transplant 2000; 15: 1014-21.]. Thus, there has been a tremendous interest in developing therapies to reduce, minimize, and treat vascular development and complications, which may also have implications to vascular access creation and functional use [9Lee T, Wang Y, Arend L , et al. Comparative analysis of cellular phenotypes within the neointimal from vein segments collected prior to vascular access surgery and stenotic arteriovenous dialysis accesses. Semin Dial 2014; 27: 303-9.].

Atherosclerosis and Arteriosclerosis in CKD and ESRD

Atherosclerosis is a process, whereby, the artery wall begins to thicken as a result of deposition of calcium, cholesterol, low-density lipoproproteins, and inflammatory cells, such as macrophages. When these products are not sufficiently removed and deposit within the vessel wall, the process of plaque formation and development (atheroma) initiates [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.,18Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340: 115-26.,19Fuster V, Fallon JT, Badimon JJ, Nemerson Y. The unstable atherosclerotic plaque: clinical significance and therapeutic intervention. Thromb Haemost 1997; 78: 247-55.].

Calcification is an important part of the atherosclerosis process and generally develops within the intimal layer of the vessel wall in patients with kidney disease [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.]. Atherosclerotic lesions are present in an intermittent pattern along the length of the artery leading to vascular stenosis and occlusions, and subsequently ischemia [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.].

Arteriosclerosis refers to stiffening and loss of elasticity of the arteries. The process typically involves arterial intima and media thickening with or without significant atherosclerotic disease [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.,20London GM, Guerin AP, Marchais SJ , et al. Cardiac and arterial interactions in end stage renal disease. Kidney Int 1996; 50: 600-8.,21Rostand SG, Gretes JC, Kirk KA, Rutsky EA, Andreoli TE. Ischemic heart disease in patients with uremia undergoing maintenance hemodialysis. Kidney Int 1979; 16: 600-11.] and is frequently characterized by increased vascular wall thickness and lumen vasodilation (vascular remodeling). The consequences of adverse vascular remodeling, referred to as poor compliance or distensibility, lead to decreased ability of the artery to hemodynamically adapt to the large pulsatile flow that occurs during intermittent ventricular ejection [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.,22London GM, Guerin AP. Influence of arterial pulse and reflected waves on blood pressure and cardiac function. Am Heart J 1999; 138: 220-4.].

The clinical and functional significance of vascular calcification in CKD and ESRD patients is very significant and important. Vascular calcification can lead to a number, a histologic and structural changes to the artery which impact vessel hemodynamics as well as elasticity [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.]. Guerin et al. have reported vascular remodeling, as measured by common carotid artery distensibility and aortic pulse wave velocity, to be proportional to the presence of vascular calcifications [16London GM. Cardiovascular calcification in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003; 14: S305-9.,17Guerin AP, London GM, Marchais SJ, Metivier F. Arterial stiffening and vascular calcification in end stage renal disease. Nephrol Dial Transplant 2000; 15: 1014-21.].

In a study by Ibels et al. [23Ibels LS, Alfrey AC, Huffer WE, Craswell PW, Anderson JT, Weil R3rd. Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med 1979; 66: 790-6.], evaluating arterial histology from uremic patients, several key findings were reported: (1) uremic arteries demonstrated the presence of fibrous neointimal hyperplasia, calcification within the internal elastic lamina, medial elastic fibers, and damage and duplication of the internal elastic lamina [23Ibels LS, Alfrey AC, Huffer WE, Craswell PW, Anderson JT, Weil R3rd. Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med 1979; 66: 790-6.], suggesting the predominance of vascular calcification within uremic vessels and providing further evidence for the loss of elasticity in CKD and ESRD and (2) the degree of neointimal thickness and vascular arterial calcium concentration correlated with the duration of uremia, suggesting acceleration of vascular arterial changes as a consequence of uremia [23Ibels LS, Alfrey AC, Huffer WE, Craswell PW, Anderson JT, Weil R3rd. Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med 1979; 66: 790-6.]. These changes to the vasculature from uremia and complications of advanced CKD may potentially impact vascular access maturation and development of future stenosis.

Biology of Vascular Calcification in CKD and ESRD

The mechanisms of vascular calcification in CKD and ESRD remain an active area of research. In this section, the mechanisms of vascular calcification will be briefly described. Vascular calcification is the end result from an imbalance between cellular mediators which promote and inhibit mineralization. In addition to proper homeostasis of vascular mineralization, the current research to date has demonstrated that one major mechanism involved in regulation of vascular calcification is vascular smooth muscle cell (VSMC) damage [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.]. Normally, VSMCs play an important role in inhibiting calcification, but in pathologic environments such as kidney disease their normal function is compromised and they develop osteogenic phenotypic changes that favor deposition of minerals that leads to calcification [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.]. It is also hypothesized that when VSMCs become apoptotic, they release apoptotic bodies which accumulate calcium and initiate the calcification process [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.-26Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 2000; 87: 1055-62.]. Furthermore, VSMCs have been reported to bud matrix vesicles from their plasma membranes [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,26Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 2000; 87: 1055-62.,27Reynolds JL, Joannides AJ, Skepper JN , et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-67.]. These small membrane bound particles form a microenvironment capable of concentrating calcium and phosphate and allowing for crystal nucleation [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,26Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 2000; 87: 1055-62.,27Reynolds JL, Joannides AJ, Skepper JN , et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-67.].

Expression of osteogenic markers such as matrix γ-carboxyglutamic acid protein (MGP) [28Bostrom K, Tsao D, Shen S, Wang Y, Demer LL. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. J Biol Chem 2001; 276: 14044-52.,29Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of GLA proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998; 8: 357-75.], osteopontin (OPN) [30O'Brien ER, Garvin MR, Stewart DK , et al. Osteopontin is synthesized by macrophage. smooth mucle.and endothelial cells in primary and restenotic human coronary atherosclerotic plaques. Arterioscler Thromb 1994; 14: 1648-56.], and bone morphogenetic protein-2 (BMP-2) [31Zebboudj AF, Imura M, Bostrom K. Matrix GLA protein. a regulatory protein for bone morphogenetic protein-2. J Biol Chem 2002; 277: 4388-94.], by VSMCs has been described to be associated with vascular calcification in vivo [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.]. Temporal gene expression studies from normal and calcified arteries, which include arteries from uremic patients, have reported that VSMCs express core binding factor (-1 (Cbfa1)/Runx2 and Sox9 [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,32Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004; 95: 560-7.,33Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 2003; 23: 489-94.] and transcription factors for osteoblastic and chondrocytic differentiation at sites of calcification from in vivo studies [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.]. When studies were performed to study the temporal expression of these proteins to evaluate the relationship with onset of calcification, the VSMCs in the normal vessel wall expressed constitutive inhibitors of calcification such as MGP [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,33Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 2003; 23: 489-94.]. However, when examining calcified arteries these inhibitors were found to be down-regulated and expression of VSMC mineralization mediators was up-regulated [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,29Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of GLA proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998; 8: 357-75.].

Studies from transgenic animal models have demons-trated the importance of a number of proteins that play an important role in vascular calcification [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.]. These include murine knockout models for MGP [34Munroe PB, Olgunturk RO, Fryns JPetal. Mutations in the gene encoding the human matrix GLA protein cause Keutel syndrome. Nat Genet 1999; 21: 142-4.], BMP-2 [29Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of GLA proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998; 8: 357-75.,31Zebboudj AF, Imura M, Bostrom K. Matrix GLA protein. a regulatory protein for bone morphogenetic protein-2. J Biol Chem 2002; 277: 4388-94.], SMAD-6 [24Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-9.,35Galvin KM, Donovan MJ, Lynch CAetal. A role for smad6 in development and homeostasis of the cardiovascular system. Nat Genet 2000; 24: 171-4.], ecto-nucleotide pyrophosphate/phosphodi-esterase 1 (ENPP1) [36Johnson K, Polewski M, van Etten D, Terkeltaub R. Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice. Arterioscler Thromb Vasc Biol 2005; 25: 686-91.], Klotho [37Nabeshima Y. [Ectopic calcification in Klotho mice]. Clin Calcium 2002; 12: 1114-7.], and Fetuin-A [38Schafer C, Heiss A, Schwarz Aetal. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 2003; 112: 357-66.].

There remain many unanswered questions about the mechanisms underlying vascular calcification and the role of CKD and uremia in accelerating the vascular calcification process. Improving our understanding of the pathophysio-logical regulation of vascular calcification may have therapeutic potential in regards to treating cardiovascular disease in kidney disease and in hemodialysis vascular access.

CLINICAL STUDIES EVALUATING VASCULAR CALCI-FICATION AND HEMODIALYSIS VASCULAR ACCESS DYSFUNCTION

Histologic Studies of Arterial Coronary Calcification

The leading cause of mortality in patients with CKD and ESRD is still cardiovascular disease [39Collins AJ, Foley RN, Herzog Cetal. US Renal Data System 2012 Annual Data Report. Am J Kidney Dis 2013; 61: A7e1-476.]. The high risk of elevated cardiovascular events is even present in early stages of CKD [40Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death. cardiovascular evnts.and hospitalization. N Engl J Med 2004; 351: 1296-305.]. Recent studies from autopsies of coronary artery samples have shed light on this theory. Schwarz et al., in a comparative study of coronary atherosclerotic lesions in autopsy samples from 27 patients with CKD (21 with ESRD) and 27 age- and sex-matched controls, demonstrated that atherosclerotic plaque was more calcified in patients with CKD compared to their control group [41Schwarz U, Buzello M, Ritz E , et al. Morphology of coronary atherosclerotic lesions in patients with end stage renal failure. Nephrol Dial Transplant 2000; 15: 218-3.]. A recent study from Nakano et al., from 126 patients reported that the proportion of advanced atherosclerotic lesions is higher at a lower estimated GFR with a higher prevalence of calcified coronary lesions and thickened arterial intima [42Nakano T, Ninomiya T, Sumiyoshi S , et al. Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. Am J kidney Dis 2010; 55: 21-30.]. However, no medial calcification was noted in this study [42Nakano T, Ninomiya T, Sumiyoshi S , et al. Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. Am J kidney Dis 2010; 55: 21-30.]. Nakamura et al., in their study of autopsied coronary arteries from subjects with different levels of CKD (stage I/II, stage III, stage IV/V, stage VD) showed that intimal calcification was present in all groups, but most prominent and severe in the CKD Stage VD group compared to CKD Stage IV/V group [43Nakamura S, Ishibashi-Ueda H, Niizuma S, Yoshihara F, Horio T, Kawano Y. Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clin J Am Soc Nephrol 2009; 4: 1892-900.]. However, medial calcification was seen in a minority of CKD Stage IV/V group [43Nakamura S, Ishibashi-Ueda H, Niizuma S, Yoshihara F, Horio T, Kawano Y. Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clin J Am Soc Nephrol 2009; 4: 1892-900.]. The collective studies above demonstrate that vascular calcification progressively worsens with decline of kidney function. All studies have demonstrated the presence of intimal calcification, with calcification less prominent within the media.

Vascular Calcification in Upper Extremity Vessels and Vascular Access

There are several studies that have documented the presence of vascular calcification in upper extremity vessels used to create new vascular access. Wang et al., collected 30 radial artery specimens from ESRD patients at the time of new arteriovenous fistula creation and found that 37% of arteries had calcification (20% mild/moderate and 17% severe calcification) [44Wang N, Yang J, Yu X , et al. Radial artery calcification in end stage renal disease patients is associated with deposition of osteopontin and diminished expression of alpha-smooth muscle actin. Nephrology 2008; 13: 367-75.] with calcium deposition primarily located in the medial layer of the artery. In a study of 65 patients, Kim et al., reported that micro-calcification from radial and brachial arteries, using von Kossa staining, was present in 55.4% of patients [45Kim HG, Park SC, Lee SL , et al. Arterial micro-calcification of vascular access is associated with aortic arch calcification and arterial stiffness in hemodialysis patients. Semin Dial 2013; 26: 216-2.]. Calcification was primarily observed in the medial layer (unlike coronary arteries) and not seen in the intimal layer [45Kim HG, Park SC, Lee SL , et al. Arterial micro-calcification of vascular access is associated with aortic arch calcification and arterial stiffness in hemodialysis patients. Semin Dial 2013; 26: 216-2.]. Venous calcification and vascular access outcomes were not reported in this study. Lee et al., using Von Kossa staining evaluated 67 veins collected at the time of new vascular access creation [46Lee T, Safdar N, Mistry MJ , et al. Pre-existing venous calcification prior to dialysis vascular access surgery. Semin Dial 2012; 25: 592-.]. Twenty-two of 67 (33%) samples showed the presence of venous calcification [46Lee T, Safdar N, Mistry MJ , et al. Pre-existing venous calcification prior to dialysis vascular access surgery. Semin Dial 2012; 25: 592-.]. Among the subset of patients with documented venous calcification, 4/22 (18%), 19/22 (86%), 22/22 (100%), and 7/22(32%) had calcification present within the endothelium, intima, media, and adventitia, respectively [46Lee T, Safdar N, Mistry MJ , et al. Pre-existing venous calcification prior to dialysis vascular access surgery. Semin Dial 2012; 25: 592-.]. This study did not report the association of pre-existing venous calcification with vascular access outcomes. Finally, Allon et al., in 50 CKD patients undergoing AVF placement, reported arterial micro-calcification in 2/3 of arterial samples [8Allon M, Litovsky S, Young CJ , et al. Medial fibrosis. vascular calcificaion.intimal hyperplasia., and arteriovenous fistula maturation. Am J Kidney Dis 2011; 58: 437-.]. Among samples with the presence of arterial micro-calcification, there was a trend towards an association with AVF non-maturation [8Allon M, Litovsky S, Young CJ , et al. Medial fibrosis. vascular calcificaion.intimal hyperplasia., and arteriovenous fistula maturation. Am J Kidney Dis 2011; 58: 437-.].

There are also several studies that have evaluated vascular calcification after vascular access creation. Schlieper et al., found in a study of 212 patients that 49 patients (23%) had presence of vascular access calcification (in AVF and AVG) using plain X-ray [47Schlieper G, Kruger T, Djuric Z , et al. Vascular access calcification predicts mortality in hemodialysis patients. Kidney Int 2008; 74: 1582-7.]. Furthermore, they reported that the presence of vascular access calcification was significantly associated with patient mortality [47Schlieper G, Kruger T, Djuric Z , et al. Vascular access calcification predicts mortality in hemodialysis patients. Kidney Int 2008; 74: 1582-7.]. Finally, Touissant et al., in 28 hemodialysis patients, using computed tomography imaging fistulograms, showed that vascular calcification was predominately within the aorta (75%) and subclavian arteries (89.3%), but minimal vascular calcification was present at the level of the AVF [48Toussaint ND, Lau KK, Polkinghorne KR, Kerr PG. Measurement of vascular calcification using CT fistulograms. Nephrol Dial Transplant 2007; 22: 484-90.].

The studies above, collectively, demonstrate the presence of both calcification in both veins and arteries used to create new vascular access with possible association with mortality when detected after vascular access creation. There is an urgent need for more investigative studies to understand the pathophysiological mechanisms of calcification development in arteries and veins prior to and after vascular access creation.

FUTURE PERSPECTIVES

Cardiovascular disease remains one of the leading causes of death in advanced CKD patients and a major contributing factor in cardiovascular mortality in ESRD patients [39Collins AJ, Foley RN, Herzog Cetal. US Renal Data System 2012 Annual Data Report. Am J Kidney Dis 2013; 61: A7e1-476.]. In addition, vascular calcification, not only contributes to the high prevalence of cardiovascular disease, but also likely influences successful vascular access creation, maturation, and long-term patency of AVF and AVG. Future research needs to be focused on how the uremic milieu accelerates vascular calcification and disrupts endothelial function. Recognizing that vascular calcification appears to be a regulated process, identifying key pro-calcification and inhibitory factors will be crucial to understand the role of vascular calcification as it relates to vascular access dysfunction. One approach is to develop AVFs in animal models targeting the vascular calcification process, where specific genes related to vascular calcification, such as Klotho and osteoprotegerin are knocked out. Another key question is whether vascular access calcification worsens after creation of the vascular access and use of dialysis. There are no clinical studies to date that have evaluated the role of vascular calcification of the brachial or radial arteries in the same individual prior to vascular and after access creation, or the natural progression of vascular calcification in AVFs in experimental models. The mechanisms leading to calcification in AVFs may be different from those leading to calcification seen in coronary arteries due to local hemodynamic effects and injury at the arteriovenous anastomosis, thus, development of experimental models is crucial to determine the role of calcification in vascular access, particularly AVF maturation.

CONCLUSION

Vascular calcification is present in both arteries and veins, used to create new vascular access. Future studies in this area need to focus on the mechanisms that lead to vascular calcification in the uremic milieu and the impact of calcification on vascular access outcomes. The complex pathogenesis of vascular calcification is still poorly understood, thus the prevention and progression of vascular calcification will likely require a multi-faceted therapeutic approach.

CONFLICT OF INTEREST

The author confirms that this article content has no conflict of interest.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

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