A Simplified Approach to the Diagnosis of Atypical HUS: Clinical Considerations and Practical Implications

Table 1: Serum creatinine level, platelet count and antinuclear antibodies in thrombotic thrombocytopenic purpura.

Variable	Ferrari et al. n=35	Coppo et al.* n=160	Vesely et al.* n=18	Scully et al. n=80
Serum creatinine, mean (mg/dL)	1.26±0.59	1.29±0.77	1.8±1.2	1.1 (0.6-5.8)
Serum creatinine ≥ 2.26 mg/dL	8.6%	N/A	16.7%	N/A
Platelet count, mean (×109/L)	17.4±13.7	17.4±14.2	11.6±6.9	13.5 (4-84)
Platelet count ≥ 30 (×109/L)	11.4%	N/A	0%	N/A
Antinuclear antibodies	N/A	53%	N/A	N/A

Data are expressed as mean ± standard deviation or percentage. * Patients with severe ADAMTS13 deficiency (less than 5% of normal activity). Numbers in parenthesis refer to the range of variable. N/A, not available.