| Clinical Parameters | Acute Post-Streptococcal GN | IgA GN | HSP Nephritis |
|---|---|---|---|
| Preceding URI | Streptoccocal infection 10-14 days before onset of gross hematuria. Pyoderma associated APSGN: latent period may be up to 6 weeks | 24-72 hours before onset of hematuria [synpharyngetic]. URI is often viral in nature. | May have preceding streptococcal infection. Streptococcal antibodies positive in 25-30% |
| Duration of hematuria | 7-14 days | 2-14 days. Recurrent gross hematuria with URI. | Gross hematuria occurs in minority of patients. Microhematuria is more common |
| Microhematuria | Can persist up to 1 year | Can persist, but may disappear in between gross hematuria. | Microhematuria is common, usually resolves in few weeks. |
| Serum complement C3 | Low | Normal | Normal |
| Other Clinical associations | Hypertension Hyperkalemia Oliguria Mild azotemia | Acute kidney injury Nephrotic syndrome | Typical rash Joint pains Abdominal pain Risk for intessusception |
| Renal Biopsy finding | Sub-epithelial “humps” - electron dense deposits | Mesangial cell and matrix proliferation Mesangial IgA, IgG and C3 complement deposits | Mesangial cell and matrix proliferation Mesangial IgA, IgG and C3 complement deposits |
| Prognosis | Excellent | Long-term risk of CKD and hypertension. | Risk of CKD in only those with severe renal pathology. Most patients recover |