Clinical Parameters |
Acute Post-Streptococcal GN |
IgA GN |
HSP Nephritis |
Preceding URI |
Streptoccocal infection 10-14 days before onset of gross hematuria.
Pyoderma associated APSGN: latent period may be up to 6 weeks |
24-72 hours before onset of hematuria [synpharyngetic]. URI is often viral in nature. |
May have preceding streptococcal infection.
Streptococcal antibodies positive in 25-30% |
Duration of hematuria |
7-14 days |
2-14 days. Recurrent gross hematuria with URI. |
Gross hematuria occurs in minority of patients. Microhematuria is more common |
Microhematuria |
Can persist up to 1 year |
Can persist, but may disappear in between gross hematuria. |
Microhematuria is common, usually resolves in few weeks. |
Serum complement C3 |
Low |
Normal |
Normal |
Other Clinical associations |
Hypertension
Hyperkalemia
Oliguria
Mild azotemia |
Acute kidney injury
Nephrotic syndrome |
Typical rash
Joint pains
Abdominal pain
Risk for intessusception |
Renal Biopsy finding |
Sub-epithelial “humps” - electron dense deposits |
Mesangial cell and matrix proliferation
Mesangial IgA, IgG and C3 complement deposits |
Mesangial cell and matrix proliferation
Mesangial IgA, IgG and C3 complement deposits |
Prognosis |
Excellent |
Long-term risk of CKD and hypertension. |
Risk of CKD in only those with severe renal pathology. Most patients recover |