| Gene | Protein | Inheritance | Onset | Comments |
|---|---|---|---|---|
| α-5 chain | α-5 chain | X-linked | Early childhood | Alport syndrome - ESRD at 2-4 decade, Deafness |
| Heterozygous α-3 or α-4 mutation | α-3 or α-4 chain | AD | Early childhood | Thine basement membrane disease -Familial hematuria |
| Homozygous α-3 or α-4 mutation | α-3 or α-4 | AR | Early childhood | Alport syndrome - ESRD at adolescence, deafness |
| LAMB2 | Laminin 2 | AR | Infancy | Pierson syndrome - Eye disease, MR |
| LMX1B | LMX1B | AD | Variable | Nail-Patella syndrome - Dysplastic nails and patellae, variable degree of renal involvement |
| ITGA3 | Integrin α3 subunit | AR | Infancy | Kidney disease, lung disease, epidermolysis bullosa |