Table 2: Major classes of Diuretics used in CRS.

Generic Name Class Initial Dose (mg) Comments
Furosemide (Frusemide) Loop 80 IV; PO equivalent is~twice the IV dose.
Most commonly (ab)used diuretic!
Bumetanide Loop 0.5 Oral and IV doses are the same
Torsemide Loop 5-10 Best oral availability
Ethacrynic acid Loop 50 Used if allergic to furosemide
Hydrochlorothiazide Thiazide 12.5 PO; Weak diuretic per se-used with frusemide for sequential tubular blockade of Na reabsorption
Metolazone Thiazide 2.5 Only available orally; high risk of hypokalaemia