Fig. (3) Reduction in Initiation of Transcription during Noncytolytic CD8⁺ T cell mediated Suppression of HIV Replication. Both JR-HVS and HS-HVS significantly suppressed viral transcription initiation more than the HIV naїve CD8⁺ T cells (nEW CD8⁺), p < 0.001 for both comparisons, Student t-Test. The fold difference between the suppressed and nonsuppressed viral cultures were determined by quantifying cDNA copy numbers from the short RNA transcripts using real time PCR.