| Immunization Schedule | Adjuvant | Challenge: Dose and Route | Immune Correlates of Survival | |
|---|---|---|---|---|
| Vaccinia viruses encoding NiV F or G (hamsters) | 2 subcutaneous doses (107 pfu per dose) 1 month apart |
None | 3 months post immunization, 1000 pfu NiV intraperitoneally | Viral load Antibodies (ELISA and SNT) |
| Canarypox viruses encoding NiV F or G (pigs) | 2 intramuscular doses (108 pfu per dose) 14 days apart |
None | 29 days post immunization, 2.5 x 105 pfu NiV intranasally | Viral load Cytokine production Antibodies (ELISA, IFA and SNT) |
| Recombinant HeV or NiV soluble G (cats) | 3 subcutaneous doses (100 µg per dose) 14 days apart |
CSIRO triple adjuvant | 11 weeks post immunization, 500 TCID50 NiV subcutaneously | Viral load Antibodies (SNT) |