Virus | Modifications | Experimental | Clinical trials | References | |
---|---|---|---|---|---|
Herpes simplex virus | T-vec | ICP34.5 deletion, US11deletion, GM-CSF insertion |
+ | + | 14, 15, 16, 65, 117 |
HF10 | UL56 deletion | + | + | 161 | |
IL-2 insertion | + | - | 129 | ||
Vaccinia virus | JX-594 | GM-CSF insertion, TK deletion | + | + | 14, 66, 117 |
Reovirus | Reolysin | None | + | + | 152 |
Coxsackie virus | Cavatak | None | + | + | 162 |
Adenovirus | Tyrosinase promoter/enhancer insertion | + | - | 84 | |
IL-18 insertion | + | - | 107 | ||
IL-12 and B7 insertion | + | - | 123 | ||
Decorin insertion | + | - | 102 | ||
Vesicular stomatitis virus | Insertion of TAAs from melanoma cDNA library | + | - | 115 | |
CD40L insertion | + | - | 121 | ||
Influenza virus | NS1 deletion | + | - | 93 | |
Newcastle disease virus | IL-2 insertion | + | - | 127, 128 | |
Measles virus | Encoding anti-CTLA-4 and anti-PDL1 | + | - | 126 | |
Retrovirus | Insertion of anti-HMWMAA | + | - | 75, 76, 77 |