APPENDIX C The amphipathic and hydrophobic nature of C5A controls the ability of the short peptide to prevent vaginal and rectal HIV transmission in humanized mice. Same as Appendix.(A) except that indicated on the right are the amino acid sequences of the C5A peptides (100 µM) applied vaginally (A) or rectally (B) 15 min prior to a vaginal (A) and rectal (B) HIV (JR-CSF) challenge.