Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice

Table 3: Effect of amino acid sequence modifications on capacity of C5A to inhibit vaginal and rectal HIV transmission.

C5A Variant (100 μM)	% Protection (n=10)
C5A Variant (100 μM)	Vaginal	Rectal
C5A	100% (10/10)	100% (10/10)
C5A-C	100% (10/10)	100% (10/10)
C5A-N	100% (10/10)	100% (10/10)
C5A-CN	0% (0/10)	0% (0/10)
C5A-NA	0% (0/10)	0% (0/10)
C5A-HS	0% (0/10)	0% (0/10)