Table 1: Clinicobiological data and outcome of outbreak patients. CRP: C reactive protein, CSF: Cerebrospinal Fluid. EV RT-PCR: Enterovirus Real-Time Polymerase Chain Reaction. * Fischer’s exact test. § Antibiotics (n=7), Aciclovir (n=2). Bold: significant differences.

	All Patients (n=18)	A) Neonates and      Children < 15 Years with Comorbidity (n=3)	B) Children < 15 Years without Comorbidity (n=5)	C) Adult Patients >15 years (n=10)	p B vs C	p B vs A
Male sex (n,%)	10 (55.55)	2 (66.66)	2 (40.00)	6 (60.00)	0.60*	0.99*
Reims urban district (n,%)	13 (72.22)	1 (33.33)	4 (80.00)	8 (80.00)	0.99*	0.46*
Comorbidity (n,%)	5 (27.77)	2 (66.66)	0 (0)	3 (30.00)	0.50*	0.10*
Apyrexia (n,%)	5 (27.77)	1 (33.33)	2 (40.00)	2 (20.00)	0.56*	0.99*
Absence of neck stiffness (n,%)	9 (50.00)	2 (66.66)	3 (60.00)	4 (40.00)	0.60*	0.99*
Median CRP (mg/L) [range]	16 [0.6-108]	55 [10.4-108]	26.5 [16-40]	12.5 [0.6-58]	0.25	0.47
Median White Blood cells count Blood(G/L) [range]	10.8 [4.7-22.2]	16.7 [13-22]	10.1 [9.9-15.4]	10.6 [4.7-16.7]	0.99	0.07
Median White Blood cells count CSF(n/mm3) [range]	67.5 [0-870]	35 [35-90]	26 [1-198]	149 [0-870]	0.32	0.65
Median Protein concentration (mg/L) [range]	424 [166-1240]	1108 (684-1240]	198 [166-520]	424 [264-1040]	0.02	0.02
CSF interferon alpha level >2UI/ml (n,%)	8 (44.44)	1 (33.33)	1 (20.00)	6 (60.00)	0.55*	0.99*
Median EV RT-PCR turnaround time (hours) [range]	47 [7-120]	21 [7-46]	48 [30-51]	50 [18-120]	0.38	0.09
Discharged before EV RT-PCR Results released (n,%)	8 (44.44)	0 (0)	5 (100.00)	3 (30.00)	0.02*	0.01*
Brain imaging prescribed (n,%)	6 (33.33)	1 (33.33)	0 (0)	5 (50.00)	0.10*	0.37*
Median Hospitalization length (days) [range]	3.5 [1-14]	12 [7-14]	2 [1, 2]	4 [2-5]	0.003	0.01
Anti infective treatment prescribed§ (n,%)	7 (38.80)	3 (100.00)	0 (0)	4 (40.00)	0.23*	0.01*
Post-lumbar puncture intracranial hypotension (n,%)	1 (5.55)	0 (0)	1 (20.00)	0 (0)	0.33	0.99*