Table 1: Past, Present and Pending oHSV Trials in Patients with Malignant Glioma

Virus	Parent Strain	Tumor-Targeting Mutation(s)	Trial Description	Trial Status	References
HSV1716	17	Both γ134.5 gene copies deleted	Phase 1 dose escalation, safety	closed	[21].
			Phase 1b, single dose, assess intratumoral virus replication	closed	37]
			Phase Ib, safety of resection cavity administration	closed	[38]
			Phase III	ongoing	nexxusscotland.com website
G207	F	Both γ134.5 gene copies deleted, lacZ gene inserted into UL39 gene	Phase 1 dose escalation, safety	closed	[20]
			Phase Ib, two dose regimen, one intratumor, one into resection cavity	closed	[17]
			Phase Ib	closed	Markert et al., submitted
M032	F/M002	Both γ134.5 gene copies deleted	Phase I, safety and dose escalation	pending	[15]
C134	F/C101	Both γ134.5 gene copies deleted, HCMV gene IRS1 introduced within UL3/UL intergenic region	Phase I safety and dose escalation	planning stages	[16]