Fig. (1) a) Multiferon inhibits more efficiently the replication cycle of CCHFV compared to the others commercially available interferons. A549 cells were treated with different concentrations of IFNs for 24h. Mock-treated and IFN-treated cells were then infected with CCHFV (MOI 1). After another 48h cell supernatants were collected and analyzed by real-time RT-PCR. Error bars demonstrate ± SD based on three separate experiments. b) Comparison of inhibition of CCHFV genome contents in cell supernatants after pre-treated with different concentrations of Multiferon. A549 cells were treated with different concentrations of Multiferon for 24h. The mock-treated and Multiferontreated cells were then infected with CCHFV (MOI 0,1 and 1). After another 48h cell supernatants were collected and analyzed by real-time RT-PCR.