| Protective Factor | Nature of Factor | Type of Transmission Involved |
|---|---|---|
| Delta 32 Mutation | Genetic | Sexual and parenteral transmission of R5 strains |
| Other polymorphisms in HIV-1 coreceptors | Genetic | Sexual, vertical and parenteral |
| SNPs in RANTES, MIP-1α /β and DEFB1 genes | Genetic | Sexual and vertical |
| HLA alleles | Genetic | Vertical and sexual |
| High frequency of KIR3DL1, KIR2DL2 and KIR2DL5 | Genetic | Sexual |
| Apoptosis of monocytes | Innate immune response | Sexual |
| Production of cytokines by NK cells | Innate immune response | Sexual and parenteral |
| Activity and phenotype of DC | Innate immune response | Vertical |
| Soluble proteins: APOBEC3G, CAF, defensins, IFNs, LIF, MIP-1α/β, RANTES, RNases, SDF-1, SLPI and TRIM-5α | Innate immune response | Sexual and vertical |
| Production of specific IgA | Humoral immune response | Sexual and vertical |