Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing Antibodies

Table 1: The Molecular Targets and IC₅₀ Values of the Antibodies Evaluated in this Study, and the HIV-1 Strains they Inhibit

Antibody	Molecular Target	HIV Isolates Inhibited	Target Cells Used for IC₅₀ Determination for IIIB	IC₅₀ for HIV-1_IIIB (µg/ml)^‡	References
IgG1 b12	gp120	IIIB, MN and some primary isolates	H9^†	0.007	[⁸]
2G12	gp120	IIIB, RF, MN (weakly), SF2 (weakly)	AA-2	0.02	[⁹] [¹⁰]
IgG1 m14	gp120	IIIB (HxB2), JRCSF, 89.6, Yu2	U87.CD4.CCR5.CXCR4	1.0	[¹¹]
4E10	gp41	IIIB, MN, RF (weakly) & broad range of isolates	AA-2^§	1.0^§	[⁷]
2F5	gp41	IIIB, MN, SF2 & broad range of isolates	H9 U937 PBMC	0.3 0.13 0.8	[⁶]

^‡ IC₅₀ values were derived from infectivity measurements utilizing free virus, and subsequent p24 production, unless indicated otherwise.

^§ Cells were infected with cell-free virus and syncytium formation after 5 days was used as the readout.

^† IC₅₀ values were derived from a plaque assay.