Loss of HPV16 E2 Protein Expression Without Disruption of the E2 ORF Correlates with Carcinogenic Progression

Fig. (1) Schematic representation of the HPV16 early transcripts according to previously published map [5]. A) The P₉₇ early promoter is shown as well as the structure of the HPV16 genome with the organization of the ORF of early genes on the DNA. The main early transcripts and the ORF that they contain are also shown. Localization of the NanoString probes relative to the viral ORFs is indicated as well as the early Poly A signal by a black dot. B) Recognition of the 9 different transcripts, as numbered in A, by the three NanoString probes.