Fig. (1) HPV Long Control Region. (A) Schematic map of the long control region of HPV16. The end of the L1 and beginning of the E6 ORF are indicated. The E2 binding sites (E2BS) are numbered from 1 to 4 and colored in red. (B) Schematic representation of a prototypic genital HPV LCR with the position of the E2 and E1 binding sites. (C) Schematic representation of a prototypic cutaneous HPV LCR with the position of the E2 and E1 binding sites.