Fig. (3) Functional gathering of E2 interacting partners. DAVID analysis was performed on the E2 known interacting partners based on their associated GO (Gene Ontology) terms. Several parameters were taken into account to extract the four main categories: high enrichment score (A), low p-value (B), and high prevalence (C). (D) Representation of the four main functional families targeted by E2. Cellular proteins shared by different categories are multi-colored. The network representation was generated by Cytoscape [122].