Fig. (4) Complex regulation of transcriptional mechanisms. (A) Known E2 interacting partners of the transcription family and their associated function either as transcription regulators or chromatin factors. (B) Summary of the interaction strength detected between 12 E2 proteins and cellular proteins involved in regulation of transcription. The symbol “-” stands for a lack of interaction and from “+” to “+++”, an increasing strength of interaction as measured in [15] (C) Gathering of E2 targets involved in transcription regulation by main function. (D) Representation of E2 association with the SNF2H-related chromatin remodeling complexes.