Table 1.: Literature Curated Interactions. List of Interactions Found for the HPV E2 Proteins in the VirHostNet, virusMINT and PubMed Databases

ENSembl ID Official Gene Symbol Name Synonyms HPV Type Refs.
ENSG00000065000 AP3D1 adaptor-related protein complex 3, delta 1 subunit ADTD HPV16 [123]
ENSG00000012048 BRCA1 breast cancer 1, early onset BRCC1, PPP1R53, RNF53 HPV18 [124]
ENSG00000141867 BRD4 bromodomain containing 4 CAP, HUNK1, HUNKI, MCAP HPV16,18,31,11,6,8,1 [55, 125, 126]
ENSG00000064726 BTBD1 BTB (POZ) domain containing 1 HPV16 [90]
ENSG00000133243 BTBD2 BTB (POZ) domain containing 2 HPV16 [90]
ENSG00000108561 C1QBP complement component 1, q subcomponent binding protein gC1Q-R, gC1qR, HABP1, p32, SF2p32 HPV5 [60]
ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase Casp-8, FLICE, MACH, MCH5 HPV16,18 [66]
ENSG00000206355 CCHCR1 coiled-coil alpha-helical rod protein 1 C6orf18, HCR HPV16 [90]
ENSG00000117399 CDC20 cell division cycle 20 homolog CDC20A, p55CDC HPV16,18 [7]
ENSG00000245848 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha C/EBP-alpha, CEBP HPV16,18,8 [103]
ENSG00000172216 CEBPB CCAAT/enhancer binding protein (C/EBP), beta C/EBP-beta, CRP2, IL6DBP, LAP, NFIL6, TCF5 HPV16,18,8 [103]
ENSG00000003402 CFLAR CASP8 and FADD-like apoptosis regulator c-FLIP, CASH, CASP8AP1, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT HPV16 [68]
ENSG00000160917 CPSF4 cleavage and polyadenylation specific factor 4 CPSF30, NAR HPV16 [62]
ENSG00000005339 CREBBP CREB binding protein CBP, KAT3A, RSTS, RTS HPV18 [31]
ENSG00000036257 CUL3 cullin 3 HPV16 [88]
ENSG00000013573 DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 CHL1, CHLR1, KRG2 HPV16,11 [56]
ENSG00000242372 EIF6 eukaryotic translation initiation factor 6 b(2)gcn, EIF3A, ITGB4BP, p27BBP HPV16 [123]
ENSG00000100393 EP300 E1A binding protein p300 KAT3B, p300 HPV18,5,8 [32]
ENSG00000183495 EP400 E1A binding protein p400 CAGH32, DKFZP434I225, KIAA1498, KIAA1818, P400, TNRC12 HPV16 [23]
ENSG00000105325 FZR1 fizzy/cell division cycle 20 related 1 CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242 HPV16,18 [7]
ENSG00000204628 GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Gnb2-rs1, H12.3, RACK1 HPV16 [123]
ENSG00000132522 GPS2 G protein pathway suppressor 2 HPV16 [127]
ENSG00000137947 GTF2B general transcription factor IIB TFIIB HPV16 [128]
ENSG00000180806 HoxC9 homeobox C9 HOX3, HOX3B HPV16 [90]
ENSG00000114166 KAT2B K(lysine) acetyltransferase 2B GCN5, GCN5L, P/CAF, PCAF HPV16,18,11,6 [30]
ENSG00000126012 KDM5C lysine (K)-specific demethylase 5C DXS1272E, JARID1C, SMCX, XE169 HPV16 [23]
ENSG00000112984 KIF20A kinesin family member 20A RAB6KIFL HPV16,11 [57]
ENSG00000135679 MDM2 Mdm2 p53 binding protein homolog HDM2, HDMX, MGC5370 HPV16 [129]
ENSG00000187109 NAP1L1 nucleosome assembly protein 1-like 1 MGC23410, MGC8688, NAP1, NAP1L, NRP HPV18,5,8 [34]
ENSG00000123358 NR4A1 nuclear receptor subfamily 4, group A, member 1 GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3 HPV16 [70]
ENSG00000104904 OAZ1 ornithine decarboxylase antizyme 1 AZI, MGC138338, OAZ HPV16 [123]
ENSG00000143799 PARP1 poly (ADP-ribose) polymerase 1 ADPRT, PARP, PPOL HPV18 [130]
ENSG00000166851 PLK1 polo-like kinase 1 PLK HPV5 [131]
ENSG00000132963 POMP proteasome maturation protein C13orf12, HSPC014, UMP1 HPV16 [123]
ENSG00000214517 PPME1 protein phosphatase methylesterase 1 PME-1 HPV16 [123]
ENSG00000168066 SF1 splicing factor 1 ZFM1, ZNF162 HPV16 [90]
ENSG00000136450 SFRS1 serine/arginine-rich splicing factor 1 ASF, MGC5228, SF2, SF2p33, SFRS1, SRp30a HPV5 [60]
ENSG00000161547 SFRS2 serine/arginine-rich splicing factor 2 PR264, SC-35, SC35, SFRS2, SFRS2A HPV5 [60]
ENSG00000115875 SFRS7 serine/arginine-rich splicing factor 7 9G8, AAG3, HSSG1, RBM37, SFRS7, ZCCHC20, ZCRB2 HPV5 [60]
ENSG00000145604 SKP2 S-phase kinase-associated protein 2 (p45) FBL1, FBXL1 HPV18 [85]
ENSG00000099956 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 BAF47, hSNFS, Ini1, RDT, Sfh1p, SNF5L1, Snr1 HPV18 [33]
ENSG00000172062 SMN1 survival of motor neuron 1, telomeric BCD541, SMA, SMA1, SMA2, SMA3, SMA@, SMNT HPV16,18,11 [64]
ENSG00000104852 SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) RNPU1Z, RPU1, Snp1, SNRP70, U1-70K HPV5 [58]
ENSG00000185591 SP1 Sp1 transcription factor HPV18,8 [39. 132]
ENSG00000147133 TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, NSCL2, TAF2A, TAFII250 HPV16,18 [133]
ENSG00000106290 TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa MGC:8964, TAF2E, TAFII70, TAFII80, TAFII85 HPV18 [134]
ENSG00000178913 TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa TAF2F, TAFII55 HPV5 [135]
ENSG00000106052 TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 CALCOCO3, TXBP151 HPV16,18 [91]
ENSG00000112592 TBP TATA box binding protein GTF2D1, SCA17, TFIID HPV16,8 [135]
ENSG00000144747 TMF1 TATA element modulatory factor 1 ARA160, TMF HPV16 [90]
ENSG00000064419 TNPO3 transportin 3 IPO12, MTR10A, TRN-SR, TRN-SR2 HPV5 [60]
ENSG00000198900 TOP1 topoisomerase (DNA) I HPV16 [78]
ENSG00000163781 TOPBP1 topoisomerase (DNA) II binding protein 1 KIAA0259, TOP2BP1 HPV16 [136]
ENSG00000141510 TP53 tumor protein p53 LFS1, p53 HPV16,18 [9,137]
ENSG00000136527 TRA2B transformer 2 beta homolog Htra2-beta, SFRS10 HPV5 [60]
ENSG00000082512 TRAF5 TNF receptor-associated factor 5 RNF84 HPV1,3,5,6,8,9,11,16,18,33,39 [5]
ENSG00000175104 TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase RNF85 HPV1,3,5,6,8,9,11,16,18,33,39 [5]