Table 1.: Epidemiologic Studies Evaluating Recurrent Detection of Type-Specific HPV Following a Period of Non-Detection

Column1 Study Population Sample Size at Risk of Recurrence HPV Detection Age Mean Follow-Up Sampling Interval Incidence or Proportion of Recurrent Detection Cumulative Proportion with New Partner Recurrence Associated with New Partner?
Trottier, et al. Cancer Res 2010; 70 [21] Ludwig-McGill Cohort Study, Brazil 566 MY09/11 PCR; 38 types mean 32.7 (18.59) 59.0 months Y1: every 4 months Y2+: every 6 months all types 1.5 (0.9-2.3) per 1000 woman-mo 19.3% 3.7 (1.1-13.8)a
Insinga, et al. CEBP 2010; 19 [6] Placebo arm of Merck Protocol V501-012 Gardasil trial 827 Merck PCR; 9 types 16-23 up to 48 months every 6 months 8.2% (est from Table 4) 16.3% Not significant, no estimate reported
Rodriguez, et al. Int J Cancer 2011 Epub ahead of print doi: 10.1002/ijc.27418 Guancaste Cohort Study, Costa Rica 1052 MY09/11 PCR; 50 types range 18-84 7.01 years (IQR 6.95-7.05) yearly or semi-annually 7.7% not reported 7/81 (8.6%) of reappearing infections occurred in women reporting a new sex partner
Winer, et al. CEBP 2011; 20 [4] University of Washington students 173 PGMY09/11 PCR; 37 HPV types 19.2 (SD 1.5) 24.3 months (SD 15.7) every 4 months 19.4% not reported not reported

a Adjusted relative risk (95% confidence interval) of type-specific 're-infection' among women reporting new sexual partners.