Table 1.: Comparison of siRNA with Current Treatments
siRNA
Chemo/radiation
Vaccine
Target
All HPV Genes
All cells
L1, L2
Prophylactic
✓
✘
✓
Therapeutic
✓
✓
✘
Long-lasting
✘
✘
✓
Specificity
High
Low
High
HPV types
All
All
2-4
Warts
✓
✘
✓
CIN/AIN/VIN
✓
✓
✓
Laryngeal
Papillomatosis
✓
✓
✓
SiRNA therapies show major advantages over other forms of treatment including
specificity, broad application and reduced toxicity. CIN, cervical intraepithelial
neoplasia; AIN, anal intraepithelial neoplasia; VIN, vulval intraepithelial neoplasia.