Table 1.: Clinical Trials of Therapeutic Vaccine for HPV-Associated Cervical Lesion

Trial Phase Target Proteins Vaccine Vectors Inoculation Target Types
Ph-I/II [27] L1, E7 Chimera-VLP S.C. 16
Ph-II [26] E7 Hsp (SGN-00101] S.C. 16
Ph-II [28] E6, E7 Vaccinia virus (TA-HPV) I.M. 16, 18
Ph-II [29] L2, E6, E7 Fusion protein L2E6E7 (TA-CIN) I.M. 16, 18
Ph-II [30] BPV E2 Vaccinia virus (MVA-E2] intrauteral all
Ph-III [31] E6, E7 plasmid vaccine (ZYC101a) I.M. 16, 18
Ph-II [32] E6, E7 Cocktailed Synthetic peptide S.C. 16

S.C.: subcutaneous injection, I.M.: intramuscular injection, BPV: bovine papillomavirus.