EC
50 is the concentration of drugs required to reduce the replicon content in Huh7.5.1 cells by 50% as measured by luciferase activity in cell lysates. CC
50 is the concentration of drug required to inhibit cell proliferation by 50% as determined by an MTS assay. EC
50 and CC
50 were determined as previously described [
28]. Results are representative of 3 independent experiments.