Fig. (5) Titres of Influenza virus A/WSN/33 in the lungs of infected Balb/c mice infused IV with 1×10⁶ 14C2 CAR transduced spelonocytes or mock transduced splenocytes. Transduced splenocytes were transferred to the mice 1 day before intranasal infection with 500pfu of A/WSN/33. Groups of four mice were sacrificed on days 2, 4, 6, and 8 pi, and the viral titre determined in the lung by plaque assay. For days 4 and 6pi there is a statistical difference between lung titres in mock treated versus 14C2 CAR treated mice (p<0.001). Virus titres were zero on day 8 pi for both 14C2 CAR and mock treated mice. These data are representative of two independent experiments.