Detection and Genotyping of Human Papillomavirus DNA in Formalin-Fixed Paraffin-Embedded Specimens with the HPV Direct Flow CHIP System

Table 1.: Overall HPV Detection by HPV Direct Flow CHIP Using Direct PCR and Conventional PCR Protocols

	Direct PCR/ Conventional PCR	N of Samples	Agreement	Positive Agreement	Kappa Index (95% CI)	McNemar p-Value
<CIN2 (N=67)	Positive/positive	62	98.51	92.54	0.88 (0.65-1)	1
	Concordant	23
	Compatible	39
	Positive/negative	0
	Negative/positive	1
	Negative/negative	4
≥CIN2 (N=32)	Positive/positive	32	100	100	-	-
	Concordant	15
	Compatible	17
	Positive/negative	0
	Negative/positive	0
	Negative/negative	0

Concordant = exactly the same genotype(s) detected by both methods; Compatible = at least one genotype detected by both methods. N = number. CI = confidence interval.