Detection and Genotyping of Human Papillomavirus DNA in Formalin-Fixed Paraffin-Embedded Specimens with the HPV Direct Flow CHIP System

Table 2.: Detection of Multiple Infections by HPV Direct Flow CHIP Using Direct PCR and Conventional PCR Protocols

Genotypes Detected by Conventional PCR (N)	Genotypes Detected by Direct PCR (N)					Kappa Index (95% CI)	Mc Nemar p-Value
Genotypes Detected by Conventional PCR (N)	None	One	Two	Three	Four or More	Kappa Index (95% CI)	Mc Nemar p-Value
None	4	0	0	0	0	0.49 (0.37-0.62)	0.289
One	1	17	4	1	0
Two	0	11	13	6	2
Three	0	0	5	10	1
Four or more	0	0	6	1	17

N: number. CI: confidence interval.