Fig. (1) Cellular proteins associated with Ad supported AAV2 RCs. The String database (http://string-db.org/) was used to reconstitute the interaction networks between identified cellular proteins associated with Ad supported AAV2 RCs and/or the AAV2 Rep78 protein. The database lists confident known and predicted direct (physical) and indirect (functional) interactions between cellular proteins based on experimental validations. Four functional categories, mRNA processing (blue), DNA replication (red), transcription (yellow), and DNA damage sensing and repair (green) are highlighted.