Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance

Table 2.: Expected and observed amino acid mutations for the HA and NA genes found in this study.

Mutation*	Gene	Percentage (Expected)**	Percentage (Observed)
S101N	HA	0.2%	0.0%
S220T	HA	76.7%	100%
D239E	HA	5.5%	0.0%
D239G	HA	2.6%	0.0%
N387H	HA	1.7%	0.0%
E391K	HA	15.6%	30.8%
V106I	NA	85.1%	100%
D199N	NA	0.3%	0.0%
I223R	NA	0.2%	0.0%
N248D	NA	85.9%	100%
H275Y	NA	2.0%	0.0%

^* Amino acid positions are based on the H1N1pdm 09 vaccine strain A/California/07/2009.

^** Expected percentage of mutations for the HA and NA genes, based on published worldwide data [14].