The Open Arthritis Journal




(Discontinued)

ISSN: 1876-5394 ― Volume 7, 2014

Dendritic Cell Biology in Animal Models of Arthritis



Robert Benson*, James Brewer, Paul Garside , Iain B. McInnes
Division of Immunology, Infection and Inflammation, University of Glasgow, Scotland, UK

Abstract

In recent years the treatment of rheumatoid arthritis (RA) has changed considerably with the advent of novel biologic agents that target cytokines such as TNF. The impact on clinical practice has been considerable with achievement of high hurdle endpoints and reduced articular damage. Unfortunately, remission that is long lasting is rarely achieved and almost never reached in the absence of chronic drug therapy. Thus, interest in what should be the critical objective of autoimmune therapeutics – the re-establishment of self-tolerance – has become increasingly prominent. Models of experimental arthritis have only just begun to reveal the intricacies of dendritic cell (DC) biology in RA. And while manipulation of antigen presenting cells such as DCs can be used in the suppression of experimental arthritis, the basic functions and mechanisms regarding their impact is mostly obtained indirectly by inference from other autoimmune and infectious studies. Indeed, our understanding of the contribution of DC biology to induction and perpetuation of RA is relatively ill defined. Here we discuss recent advances in understanding basic DC biology, their roles in, and impact on, experimental arthropathy and resulting therapeutic implications. It is essential that more research into the direct contribution of DC activity in RA is forthcoming, particularly as they could hold the key to development of antigen specific therapeutics. The major contributing factor to this knowledge deficit is the difficulty inherent in investigating what are most likely pre-clinical immunological events, an area more suited to study in animal models.

Keyword: Dendritic cell, Arthritis, Animal model, Autoimmune, Tolerance.

Article Information


Identifiers and Pagination:

Year: 2010
Volume: 3
First Page: 24
Last Page: 31
Publisher Id: TOARTHJ-3-24
DOI: 10.2174/1876539401003010024

Article History:

Received Date: 15/5/2009
Revision Received Date: 16/10/2009
Acceptance Date: 22/10/2009
Electronic publication date: 12/1/2010
Collection year: 2010

© Benson etal.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Glasgow Biomedical Research Centre, Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, 120 University Place, Glasgow G12 8QQ, Scotland, UK; Tel: 44 141 3308412; Fax: 44 141 337 3217; E-mail: benson@clinmed.gla.ac.uk


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