The Open Clinical Cancer Journal




    (Discontinued)

    ISSN: 1874-1894 ― Volume 5, 2011

    The Changing Management of Esophageal Carcinoma: Survival in a Population Cohort 1985-1994



    T. Bates1, *, A. Antoniou2, R.E.K. Marshall3, M. Harrison1 , E.E. Bassett4
    1 Department of Surgery, William Harvey Hospital, Ashford, Kent, UK
    2 Institute of Liver Studies, Kings College Hospital, London, UK
    3 Department of Surgery, The Horton and The John Radcliff Hospital, Oxford, UK
    4 Institute of Mathematics and Statistics, University of Kent, Canterbury, (Canterbury), UK

    Abstract

    Background:

    The management of esophageal carcinoma is changing but before the introduction of chemotherapy and multidisciplinary teams, surgery became more selective. The aim of this study was to confirm this trend and to examine survival in a total population cohort 1985-94.

    Results:

    Only a quarter of 413 patients had surgery but from 1989 even fewer were operated on but there were more long-term survivors: 1/51 v. 7/58 (p<0.05). Operative mortality fell from 12% to 6.9 % in the later period (N.S.) and survival post surgery was marginally improved, 15 v. 11 months p = 0.0502. The five year survival rate doubled from 7.8% to 17.2%.

    Conclusion:

    Few studies of esophageal cancer include all cases in a defined population. This carries a very poor prognosis but the present cohort shows a slight improvement with more selective surgery and this may serve as a benchmark against which modern multidisciplinary management might be compared.

    Keywords: : Esophageal cancer, Esophagectomy, Radiotherapy, Mortality, Prognosis.


    Article Information


    Identifiers and Pagination:

    Year: 2008
    Volume: 2
    First Page: 44
    Last Page: 50
    Publisher Id: TOCCJ-2-44
    DOI: 10.2174/1874189400802010044

    Article History:

    Received Date: 20/2/2008
    Revision Received Date: 8/4/2008
    Acceptance Date: 4/7/2008
    Electronic publication date: 1/04/2008
    Collection year: 2008

    © Tom Bates; Licensee Bentham Open.

    open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


    * Address correspondence to this author at the Department of Surgery, William Harvey Hospital, Ashford, TN24 0LZ, Kent; Tel: 01233 750304; Fax: 01233 750599; E-mail: bates.tom@virgin.net




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