The Open Drug Resistance Journal


ISSN: 1876-5211 ― Volume 1, 2011

In Vitro Efficacy of Cefepime Against Multi-Drug Resistant Pseudomonas aeruginosa – An Alarming Situation in our Setup

Luqman Satti*, 1, Shahid Abbasi2, Tanveer Ahmed Qumar1, Muhammad Shoaib Khan3, Zahid Ahmed Hashmi4
1 Department of Pathology, Combined Military Hospital, Dera Ismail Khan, Pakistan
2 Consultant Microbiologist, Armed Forces Institute of Pathology, Rawalpindi, Pakistan
3 Department of Surgery, Combined Military Hospital, Dera Ismail Khan, Pakistan
4 Gomal Medical College, Dera Ismail Khan, Pakistan



Third generation cephalosporins are still most commonly used antibiotics empirically in our setup leading to emergence of resistance in this group. In this environment of increasing resistance, empirical use of this group of antibiotics would be a futile effort. Therefore, this study was conducted to evaluate the in vitro efficacy of fourth generation cephalosporin cefepime against multi-drug resistant isolates of Pseudomonas aeruginosa from various clinical specimens in our setup.

Place and Duration of Study:

Department of Pathology, Combined Military Hospital Dera Ismail Khan, Pakistan from January 2011 to May 2011.


All the clinical specimens giving growth of Pseudomonas aeruginosa were included in the study. Modified Kirby-Bauer disk diffusion method was used for sensitivity testing. Isolates resistant to three or more than three groups of antibiotics were included in the final results.


A total of 100 multi-drug resistant Pseudomonas aeruginosa isolates were cultured from various clinical specimens. Out of 100 isolates, 71% were resistant to cefepime while resistance rate of amikacin, gentamicin, ceftazidime, tazobactem/piperacillin, sulbactam/piperacillin, imipenem and polymyxin were 61%, 83%, 72%, 10%, 2%, 45% and 2% respectively.


Drug resistance in Pseudomonas aeruginosa is alarming as it is now increasing even in newer generation of drugs. It is the need of hour to follow strict hospital infection control and antibiotic policies to halt the spread of this resistance.

Keywords: Cefepime, multi-drug resistance, Pseudomonas aeruginosa.

Article Information

Identifiers and Pagination:

Year: 2011
Volume: 1
First Page: 12
Last Page: 16
Publisher Id: TODRJ-1-12
DOI: 10.2174/1876521101101010012

Article History:

Received Date: 29/5/2011
Revision Received Date: 16/6/2011
Acceptance Date: 22/6/2011
Electronic publication date: 8/7/2011
Collection year: 2011

© Satti et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: // which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Pathology, Combined Military Hospital, Dera Ismail Khan, Pakistan; Tel: +923215570838; E-mail:

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