Synthesis and Evaluation of New 2-Iminothiazolidin-4-one and Thiazolidin-2,4-dione Derivatives as Antimicrobial and Anti-inflammatory
Waleed A. Bayoumi1, *, Shaymaa H. Abdel-Rhman2, Mohamed E. Shaker3
1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516,
2 Department of Microbiology, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt;
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
A new series of 2-iminothiazolidin-4-ones and thiazolidin-2,4-diones were designed and synthesized. The target
compounds were evaluated for antimicrobial and anti-inflammatory activities, aiming to find a candidate carrying dual
activities. The antibacterial activity was determined by cup-diffusion technique and NCCLS broth dilution method. The
MICs were determined using 96-well microtitre plates, while the anti-inflammatory activity was determined using carrageenan-
induced rat paw edema model. The results revealed that target compounds showed no antifungal activity towards
tested Fungi, whereas the antibacterial activity was mainly on Gram-positive bacteria. The anti-inflammatory activity
was observed in compounds belonging to the thiazolidin-2,4-dione series. The structures of the newly synthesized
compounds were confirmed by physical and spectral data.
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* Address correspondence to this author at the Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt; Tel: +20 111 5633 722; Fax: +20 5022 4749; E-mail: firstname.lastname@example.org