Flavonoids from the Fresh Leaves of Kalanchoe tomentosa (Crassulaceae)
Lilis Siti Aisyah1, Yenny Febriany Yun1, Euis Julaeha1, Tati Herlina1, Achmad Zainuddin1, Wawan Hermawan2, Unang Supratman1, *, Hideo Hayashi3
1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363,
Sumedang, Indonesia;
2 Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University,
Jatinangor 45363, Sumedang, Indonesia;
3 Division of Applied Life Sciences, Graduate School of Life and
Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan
Abstract
Flavonoids compounds such as kaempferol (1), kaempferol-3-O-β-D-glucopyranoside or astragalin (2) and
kaempferol-3-O-α-L-rhamnoside or afzelin (3) have been isolated from the fresh leaves of Kalanchoe tomentosa
(Crassulaceae). The chemical structure of isolated compounds 1-3 were identified by spectroscopic evidences and
comparison with those compound previously reported. Compounds 1-3 showed cytotoxic activity against P-388 murine
leukimia cells with IC50 values of 51.8, > 100 and 3.32 µg/mL, respectively.
Keywords: Crassulaceae, cytotoxic activity, flavonoids, Kalanchoe tomentosa, P-388 murine leukimia cells.
Article Information
Article History:
Received Date: 28/2/2015
Revision Received Date: 11/8/2015
Acceptance Date: 16/9/2015
Electronic publication date: 13/11/2015
© Aisyah et al.; Licensee Bentham Open.
open-access license:
This is an open access article licensed under the terms of the (
https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial
use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the Department of Chemistry,
Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jl.
Raya Bandung-Sumedang Km 21, Jatinangor 45363, Sumedang, West Java, Indonesia;
Tel/Fax: +62-22-7794391; E-mail: u_supratman@unpad.ac.id
Open Peer Review Details |
Manuscript submitted on 28-2-2015 |
Original Manuscript |
Flavonoids from the Fresh Leaves of Kalanchoe tomentosa (Crassulaceae) |